Novel multi granules controlled release tablets of milnacipran: Design with simplex lattice, in-vitro characterization and pharmacokinetic predictions
نویسندگان
چکیده
منابع مشابه
Novel multi granules controlled release tablets of milnacipran: Design with simplex lattice, in vitro characterization and pharmacokinetic predictions
Aim: Milnacipran is well used drug for the treatment of depression and fi bromyalgia. Its short elimination half-life, frequent dosing and associated side effects cause lack of patient compliance and discontinuation of present therapy. To overcome such problems, the aim of the present study was to design a novel multi granules based controlled release (CR) formulation with simplex lattice techn...
متن کاملPreparation of Alprazolam Extended- Release Tablets and In vitro Characterization
Abstract The main aim of this study was to prepare and evaluate the extended - release system of an anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on the development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and polyvinylpyrrolidone (PVP k30...
متن کاملIn Vitro Studies of Controlled Release Alfuzosin Matrix Tablets Prepared with Ethylcellulose and Hydroxypropyl Methylcellulose
Extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. It is convenient for older patients to take only one tablet a day. Marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. Therefore, a less compl...
متن کاملFloating Matrix Tablets of Domperidone Formulation and Optimization Using Simplex Lattice Design
The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...
متن کاملDesign and Characterization of Controlled Release Matrix Tablets of Zidovudine
The investigation was concerned with design and characterization of oral controlled release matrix tablets of Zidovudine (AZT) in order to improve efficacy and better patient compliance. Tablets were prepared by direct compression method using various proportion of hydrophilic polymer viz; Eudragit RS100 and RL100 along or in combination with hydrophobic polymer ethyl cellulose. In vitro releas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Young Pharmacists
سال: 2014
ISSN: 0975-1483
DOI: 10.5530/jyp.2014.3.5